Subclade K Mutation Causing Surge Of Flu Cases In MN: What To Know

ST. PAUL, MN — The predicted surge of influenza cases, driven by the new “subclade K” mutation, is hitting Minnesota emergency rooms as holiday get-togethers put people in close spaces where the flu virus can easily spread.

Flu activity is high or very high in 48 states and jurisdictions, according to the latest data from the Centers for Disease Control and Prevention. At least 11 million people have gotten sick, and 5,000 people have died from the flu this season as vaccination rates wane. At least nine of those who died were children.

The CDC said the current influenza wave is expected to last several weeks. The agency also noted that RSV activity is elevated in many areas of the country, with emergency room visits and hospitalizations increasing in children under 4. COVID-19 activity is low but increasing nationally.

Respiratory illness activity in Minnesota is currently at a "very high" level, driven primarily by influenza.

The CDC’s influenza-like illness (ILI) map for the week ending Dec. 27 shows Minnesota classified at a very high activity level, indicating a sharp increase in people seeking care for flu-like symptoms.

Emergency department visits for flu in Minnesota are also at very high levels and continue to rise, while COVID-19 and RSV-related visits remain lower but are trending upward.

Community wastewater monitoring shows high viral activity for both influenza and COVID-19 across Minnesota, signaling widespread transmission even beyond confirmed clinical cases. RSV activity remains lower in wastewater data but is increasing, particularly among young children.

The Minnesota Department of Health has also reported elevated flu activity statewide, with hospitals and clinics seeing sustained pressure from influenza patients as the winter season progresses. Health officials say flu is currently the dominant respiratory virus circulating in the state, far outpacing COVID-19 and RSV in terms of overall impact.

This year’s flu season is more serious for a few reasons. One is that the subclade K mutation emerged after the vaccine was chosen for the Northern Hemisphere, last February. Once the mutation became established, there wasn’t time to develop a better-matched vaccine. That leaves more people susceptible because the virus has found a way to evade pre-existing immunity from either an infection or vaccination.

Influenza A strain H3NS has mutated seven times, making the flu a more serious threat than in years past. It caused a severe flu season around the world, including in the U.K., Canada, Japan and Australia. Recent CDC data shows that nearly all virus samples since late September were the subclade K mutation.

“Right now we’re seeing clade K everywhere we are seeing influenza” in the U.S., Andrew Pekosz, a professor and vice chair of the department of molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health, said in a pre-Christmas news conference.

Even with a mismatch, health experts advise people to get flu shots, saying they should provide some protection against severe disease and death. The CDC recommends influenza vaccination for everyone 6 months and older who has not yet been immunized this flu season. Currently, approximately 130 million doses of the flu vaccine have been distributed across the U.S.

In mid-December, the CDC estimated 42 percent of Americans had gotten their flu shots. Rates vary greatly by age, with around 60 to 70 percent of older adults over age 65 getting their shots. Coverage varies from year to year, but generally falls far short of the 70 percent goal for herd immunity. Some flu seasons have seen vaccine coverage around 47 percent.

Pekosz, speaking at a Dec. 23 news conference, said the mutations “may allow it to evade some but not all of the influenza-vaccine-induced protection.”

“We’re still in the middle of trying to figure out whether it’s producing worse illness or whether what we’re seeing is a large number of cases that are increasing, and then there’s a correspondingly similar increase in terms of the severe illness,” he said.

The advice to get vaccinated was still on the CDC website on Monday, when the agency announced a major overhaul of the childhood vaccine schedule.